4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

Base Information

Chemical Name:4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile
CAS No.:1564252-94-3
Molecular Formula:C₁₉H₁₀F₃N₅O
Molecular Weight:381.317
Hs Code.:

Synonyms:4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

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Chemical Property of 4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

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Technology Process of 4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

There total 3 articles about 4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

: 1564253-00-4
C₁₂H₅ClF₃N₃O

: 873-74-5
4-Aminobenzonitrile

: 1564252-94-3
4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.029

Reference yield:

: 672323-32-9
pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

: 1564252-94-3
4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2014.02.029

Reference yield:

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 1564252-94-3
4-(7-(2,4,6-trifluorophenoxy)pyrazolo[1,5-a]pyrimidin-5-ylamino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2014.02.029