3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL

Base Information

• Chemical Name: 3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL
• CAS No.: 77872-41-4
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.299
• Hs Code.: 2933990090
• Mol file: 77872-41-4.mol

Synonyms:3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL;1H-Indol-4-ol,3-[2-(ethylMethylaMino)ethyl]-;4-HO-MET;4-Hydroxy-N-Methyl-N-ethyltryptaMine;(3-(2-diethylaMinoethyl)-1H-indol-4-yl) acetate HCl;Metocin

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Chemical Property of 3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL

Chemical Property:

• Boiling Point: 403.051 °C at 760 mmHg
• Flash Point: 197.559 °C
• PSA: 39.26000
• Density: 1.15 g/cm³
• LogP: 2.36770

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-N-methyl-N-ethyltryptamine (4-HO-MET) is a hallucinogenic tryptamine.

Technology Process of 3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL

There total 2 articles about 3-[2-(ETHYL-METHYL-AMINO)-ETHYL]-1H-INDOL-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

Acetic acid 3-(ethyl-methyl-aminooxalyl)-1H-indol-4-yl ester (77872-26-5) → 4-hydroxy-N-methyl-N-ethyltryptamine (77872-41-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h; Heating;

DOI:10.1002/jhet.5570180131

Reference yield:

acetic acid 1H-indol-4-yl ester (5585-96-6) → 4-hydroxy-N-methyl-N-ethyltryptamine (77872-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) diethylether, 4 deg C, 18 h 2) diethylether

2: 41 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/jhet.5570180131

upstream raw materials:

Acetic acid 3-(ethyl-methyl-aminooxalyl)-1H-indol-4-yl ester

acetic acid 1H-indol-4-yl ester

Refernces