tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

Base Information

Chemical Name:tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate
CAS No.:1427158-15-3
Molecular Formula:C₂₆H₂₃ClF₃N₅O₃S
Molecular Weight:578.015
Hs Code.:

Synonyms:tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

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Chemical Property of tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

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Technology Process of tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

There total 16 articles about tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427158-09-5
N³-[4-(trifluoromethyl)phenyl][1,2]thiazolo[4,5-b]pyridine-3,7-diamine

: C₁₉H₁₉ClN₂O₆

: 1427158-15-3
tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 26 ℃; for 3h;

Reference yield:

: 1427158-10-8
3-bromo-4-chloropyridine-2-carbonitrile

: 1427158-15-3
tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 70 °C

2: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

3: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

5: trifluoroacetic acid / 2 h / 80 °C

6: sodium hydride / tetrahydrofuran / 3 h / 0 - 26 °C

With 1-methyl-pyrrolidin-2-one; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium thiomethoxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1427158-11-9
3-bromo-4-[(4-methoxybenzyl)amino]pyridine-2-carbonitrile

: 1427158-15-3
tert-butyl {4-chloro-3-[(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)carbamoyl]benzyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

2: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

4: trifluoroacetic acid / 2 h / 80 °C

5: sodium hydride / tetrahydrofuran / 3 h / 0 - 26 °C

With 1-methyl-pyrrolidin-2-one; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium thiomethoxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;