diisopropyl phosphorobromidate

Base Information

• Chemical Name: diisopropyl phosphorobromidate
• CAS No.: 80354-12-7
• Molecular Formula: C₆H₁₄BrO₃P
• Molecular Weight: 245.053
• Mol file: 80354-12-7.mol

Synonyms:diisopropyl phosphorobromidate

Chemical Property of diisopropyl phosphorobromidate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diisopropyl phosphorobromidate

There total 3 articles about diisopropyl phosphorobromidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

fuchsone (diisopropoxyphosphinyl)hydrazone → diisopropyl phosphorobromidate (80354-12-7) + p-(diphenylmethyl)benzenediazonium bromide

Guidance literature:

With bromine; In acetonitrile; for 24h; Ambient temperature;

Reference yield:

triisopropyl phosphite (116-17-6) + 2,2-dibromoacetophenone (13665-04-8) → diisopropyl phosphorobromidate (80354-12-7) + (E)-2-bromo-1-phenylvinyl diethyl phosphite + Phosphoric acid (Z)-2-bromo-1-phenyl-vinyl ester diisopropyl ester + Phosphoric acid (E)-2-bromo-1-phenyl-vinyl ester diisopropyl ester

Guidance literature:

With diethyl phosphorylchloridite; In diethyl ether; Further byproducts given; 1.) -78 deg C, 1 h, 2.) room temperature, 2 h;

Reference yield:

triisopropyl phosphite (116-17-6) + 2,2-dibromoacetophenone (13665-04-8) → diisopropyl phosphorobromidate (80354-12-7) + (Z)-2-bromo-1-phenylvinyl diethyl phosphite + Phosphoric acid (Z)-2-bromo-1-phenyl-vinyl ester diisopropyl ester + Phosphoric acid (E)-2-bromo-1-phenyl-vinyl ester diisopropyl ester

Guidance literature:

With diethyl phosphorylchloridite; In diethyl ether; Further byproducts given; 1.) -78 deg C, 1 h, 2.) room temperature, 2 h;

upstream raw materials:

triisopropyl phosphite

2,2-dibromoacetophenone

Downstream raw materials:

Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-(diisopropoxy-phosphoryloxy)-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-(diisopropoxy-phosphoryloxy)-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester

diisopropyl N-(3-methylphenyl)phosphoramidate