4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester
• CAS No.: 944054-47-1
• Molecular Formula: C₁₉H₁₈Cl₂O₂
• Molecular Weight: 349.257

Synonyms:4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Chemical Property of 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

There total 2 articles about 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(3,4-dichlorophenyl)-1-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (944054-46-0) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (944054-47-1)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2010.10.034

Reference yield:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (944054-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / Inert atmosphere

2: triethylsilane; trifluoroacetic acid / 2 h / 0 °C

With triethylsilane; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.bmc.2010.10.034

Reference yield: 80.0%

4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (944054-47-1) → [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-methanol (944054-48-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmc.2010.10.034

upstream raw materials:

4-(3,4-dichlorophenyl)-1-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

Downstream raw materials:

[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-methanol

3-bromomethyl-l-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene

C₁₇H₁₅Cl₂N₃

C₁₇H₁₅Cl₂N₃

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