ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

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Chemical Name:ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate
CAS No.:1445151-25-6
Molecular Formula:C₂₆H₂₇N₅O₄
Molecular Weight:473.531
Hs Code.:

Synonyms:ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

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Chemical Property of ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

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Technology Process of ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

There total 8 articles about ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1445153-82-1
6-(3-ethylureido)-4-(phenylamino)nicotinic acid

: 5048-82-8,198195-25-4
ethyl 4-aminocinnamate

: 1445151-25-6
ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

Guidance literature:: 6-(3-ethylureido)-4-(phenylamino)nicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 16h;

ethyl 4-aminocinnamate; With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1012878-94-2
ethyl 6-chloro-4-(phenylamino)nicotinate

: 1445151-25-6
ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16.5 h / 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / 48 h / 75 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

3.2: 3 h / 0 - 20 °C

With oxalyl dichloride; water; palladium diacetate; caesium carbonate; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1445151-25-6
ethyl (2E)-3-{4-[({6-[(ethylcarbamoyl)amino]-4-(phenylamino)pyridin-3-yl}carbonyl)amino]phenyl}prop-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic anhydride; ammonia / water / 20 h / 0 - 120 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 110 °C

3.1: hydrogenchloride / ethanol / 80 °C

4.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16.5 h / 80 °C / Inert atmosphere

5.1: water; sodium hydroxide / 48 h / 75 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

6.2: 3 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; ammonia; water; palladium diacetate; acetic anhydride; caesium carbonate; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;