N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

Base Information

Chemical Name:N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt
CAS No.:110473-20-6
Molecular Formula:C₂₆H₂₈Cl₅N₃O₇*ClH
Molecular Weight:708.25
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

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Chemical Property of N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

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Technology Process of N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

There total 6 articles about N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110473-18-2
N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-N'-(tert-butyloxycarbonyl)-D-glutamic acid methyl ester

: 110473-20-6
N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 4h;
DOI:10.1021/jo00233a006

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 110473-20-6
N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / ethanol; diethyl ether / 1 h / 0 °C

2: H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr

3: 84 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 18 h

4: aq. sodium bicarbonate / tetrahydrofuran / 11 h

5: 86 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 19 h

6: 100 percent / 4 N HCl / dioxane / 4 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00233a006

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 110473-20-6
N-(benzyloxycarbonyl)-α-(pentachlorophenyl)-D-lysyl-D-glutamic acid methyl ester, hydrochloride salt

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr

2: 84 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 18 h

3: aq. sodium bicarbonate / tetrahydrofuran / 11 h

4: 86 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 19 h

5: 100 percent / 4 N HCl / dioxane / 4 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jo00233a006