6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid

Base Information

• Chemical Name: 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid
• CAS No.: 77837-08-2
• Molecular Formula: C12H9 N O3
• Molecular Weight: 215.208
• European Community (EC) Number: 856-309-3
• UNII: 260RWO9IY8
• DSSTox Substance ID: DTXSID10475285
• Nikkaji Number: J3.279.553F
• Wikidata: Q27254026
• Mol file: 77837-08-2.mol

Synonyms:5-carboxy-pirfenidone

Chemical Property of 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 282-284°C
• Refractive Index: 1.649
• Boiling Point: 382.807°C at 760 mmHg
• Flash Point: 185.315°C
• PSA: 59.30000
• Density: 1.388g/cm³
• LogP: 1.53570
• Storage Temp.: -20°C Freezer
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 215.058243149
• Heavy Atom Count: 16
• Complexity: 365

Purity/Quality:

97% ^*data from raw suppliers

6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylicacid 95-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C=C(C=CC2=O)C(=O)O
• Uses: A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

Technology Process of 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid

There total 10 articles about 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate (77837-09-3) → 6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid (77837-08-2)

Guidance literature:

methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate; With sodium hydroxide; at 50 ℃; for 3h;

With hydrogenchloride;

DOI:10.1002/ardp.201300138

Reference yield:

aniline (62-53-3) → 6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid (77837-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol

2: NaOH-solution

With sodium hydroxide; ethanol;

Reference yield:

2H-pyran-2-one-5-carboxylic acid (500-05-0) → 6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid (77837-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol

2: NaOH-solution

With sodium hydroxide; ethanol;

upstream raw materials:

2H-pyran-2-one-5-carboxylic acid

aniline

methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate

6-oxo-1,6-dihydropyridin-3-carboxylic acid methyl ester

Downstream raw materials:

6-oxo-1-phenyl-1,6-dihydropyridine-3-deuterocarboxylic acid

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-phenyl-3-pyridinecarboxamide

6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carbonyl chloride

(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-phenyl-3-pyridinecarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 77837-08-2 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE

Send

Send

Metric Ton KG G Pound L ML

Send

Send