6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

Base Information

Chemical Name:6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde
CAS No.:1416000-54-8
Molecular Formula:C₁₆H₉ClF₃N₃O
Molecular Weight:351.715
Hs Code.:

Synonyms:6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

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Chemical Property of 6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

Chemical Property:

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Technology Process of 6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

There total 10 articles about 6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438413-72-9
C₁₆H₁₁ClF₃N₃O

: 1416000-54-8
6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 8h;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1416000-54-8
6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tert-butyl alcohol / 3 h / Reflux

2: sodium tetrahydroborate; ethanol / 24 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 8 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; ethanol; potassium carbonate; In dichloromethane; tert-butyl alcohol;

Reference yield:

: 1416000-52-6
ethyl 6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carboxylate

: 1416000-54-8
6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; ethanol / 24 h / 20 °C

2: manganese(IV) oxide / dichloromethane / 8 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; ethanol; In dichloromethane;