((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Base Information

Chemical Name:((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol
CAS No.:201857-82-1
Molecular Formula:C₂₆H₂₈O₅
Molecular Weight:420.505
Hs Code.:

Synonyms:((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

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Technology Process of ((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

There total 11 articles about ((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (4S,5R)-5-(3,4-Bis-benzyloxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester

: 201857-82-1
((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 0.75h; Ambient temperature;
DOI:10.1021/jo961587w

Reference yield: 85.0%

: (4S,5R)-methyl 5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

: 201857-82-1
((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.tetlet.2016.12.083

Reference yield:

: 5447-02-9
3,4-dibenzyloxybenzaldehyde

: 201857-82-1
((4R,5R)-5-(3,4-bis(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Na / ethanol / Ambient temperature

2: 91 percent / K₃Fe(CN)6, K₂CO₃, K₂2(OH)4>, (DHQD)2PHAL, methanesulfonamide / 2-methyl-propan-2-ol; H₂O; toluene / 72 h / Ambient temperature

3: 100 percent / p-TsOH*H₂O / dimethylformamide / 2 h / Heating

4: 97 percent / LiAlH₄ / diethyl ether / 0.75 h / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonamide; K2; sodium; potassium carbonate; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/jo961587w