3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

Base Information

Chemical Name:3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide
CAS No.:1344115-20-3
Molecular Formula:C₁₇H₁₇N₃OS
Molecular Weight:311.407
Hs Code.:

Synonyms:3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

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Chemical Property of 3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

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Technology Process of 3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

There total 3 articles about 3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 42220-74-6
2'-Hydroxy-2-methyl-chalkon

: 79-19-6
thiosemicarbazide

: 1344115-20-3
3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

Guidance literature:: With sodium hydroxide; In methanol; for 8h; Reflux;
DOI:10.1016/j.bmcl.2011.08.052

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 1344115-20-3
3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 48 h / 0 - 20 °C

1.2: 0 °C / pH 2 / Cooling with ice

2.1: potassium hydroxide / methanol / Reflux

2.2: 0 °C / pH 2 / Cooling with ice

With potassium hydroxide; sodium hydroxide; In methanol; water;
DOI:10.1021/acs.jmedchem.1c01349

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1344115-20-3
3-(2-hydroxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-carbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 48 h / 0 - 20 °C

1.2: 0 °C / pH 2 / Cooling with ice

2.1: potassium hydroxide / methanol / Reflux

2.2: 0 °C / pH 2 / Cooling with ice

With potassium hydroxide; sodium hydroxide; In methanol; water;
DOI:10.1021/acs.jmedchem.1c01349