methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

Base Information

Chemical Name:methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate
CAS No.:156143-80-5
Molecular Formula:C₁₆H₂₁NO₆
Molecular Weight:323.346
Hs Code.:

Synonyms:methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

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Chemical Property of methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

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Technology Process of methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

There total 5 articles about methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 4-(Amino-methoxycarbonyl-methyl)-benzoic acid methyl ester; hydrochloride

: 156143-80-5
methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1021/jm00035a014

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1291065-84-3
C₂₆H₄₅NO₄Sn

: 18107-18-1
diazomethyl-trimethyl-silane

: 120157-96-2
methyl 4-[N-(tert-butoxycarbonyl)aminomethyl]benzoate

: 156143-80-5
methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

Guidance literature:: carbon dioxide; C₂₆H₄₅NO₄Sn; With cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 3h; under 7500.75 Torr; Autoclave;

With hydrogenchloride; In diethyl ether; water; N,N-dimethyl-formamide; at 0 ℃; pH=2; Inert atmosphere;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; for 1h; Inert atmosphere;
DOI:10.1021/jo202597p

Reference yield:

: 71817-33-9
4-(Amino-cyano-methyl)-benzoic acid

: 156143-80-5
methyl 2-(N-tert-butoxycarbonylamino)-2-(4-methoxycarbonylphenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 6 N aq. HCl / 130 °C

2: 49 percent / SOCl₂

3: 45 percent / dimethylformamide

With hydrogenchloride; thionyl chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00035a014