(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

Base Information

Chemical Name:(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane
CAS No.:950172-17-5
Molecular Formula:C₂₂H₂₃Cl₂NO₂
Molecular Weight:404.336
Hs Code.:

Synonyms:(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

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Chemical Property of (5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

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Technology Process of (5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

There total 1 articles about (5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 99208-71-6
(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

: 950172-17-5
(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

Guidance literature:: (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

p-Cl-C₆H₄-CH₂-X; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1002/adsc.200606058

Reference yield: 91.0%

: 950172-17-5
(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

: 950172-21-1
(5S)-3,3-di(p-chlorobenzyl)-5-hydroxymethylpyrrolidin-2-one

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 3h; Heating;
DOI:10.1002/adsc.200606058

Reference yield:

: 950172-17-5
(5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane

: 4,4-di(p-chlorobenzyl)-L-proline

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / p-TsOH / methanol / 3 h / Heating

2: LAH / tetrahydrofuran / Heating

3: K₂CO₃ / tetrahydrofuran; H₂O / cooling

4: Jones reagent / acetone / -5 °C

5: H₂ / Pd/C / methanol / 20 °C / 760 Torr

With lithium aluminium tetrahydride; jones reagent; hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1002/adsc.200606058