2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Base Information

Chemical Name:2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester
CAS No.:1026081-99-1
Molecular Formula:C₂₆H₂₃N₅O₄S
Molecular Weight:501.566
Hs Code.:

2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-<i>d</i>]pyrimidine-5-carboxylic acid ethyl ester

Synonyms:2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

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Chemical Property of 2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

There total 5 articles about 2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027220-71-8
C₃₅H₃₀N₃O₄PS

: 1026081-99-1
2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 °C

2: 77 percent / sodium ethoxide / ethanol / 20 °C

3: CH₂Cl₂ / 0 - 5 °C

With sodium ethanolate; In ethanol; dichloromethane; 3: aza-Wittig reaction;
DOI:10.1021/jo048691v

Reference yield:

: C₃₉H₃₉N₄O₅PS

: 1026081-99-1
2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / sodium ethoxide / ethanol / 20 °C

2: CH₂Cl₂ / 0 - 5 °C

With sodium ethanolate; In ethanol; dichloromethane; 2: aza-Wittig reaction;
DOI:10.1021/jo048691v

Reference yield:

: 80691-81-2
2,5-diamino-thiophene-3,4-dicarboxylic acid diethyl ester

: 1026081-99-1
2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / triethylamine / hexachloroethane; acetonitrile / 4 h / 20 °C

2: CH₂Cl₂ / 12 h / 0 - 5 °C

3: CH₂Cl₂ / 20 °C

4: 77 percent / sodium ethoxide / ethanol / 20 °C

5: CH₂Cl₂ / 0 - 5 °C

With sodium ethanolate; triethylamine; In ethanol; dichloromethane; hexachloroethane; acetonitrile; 2: aza-Wittig reaction / 5: aza-Wittig reaction;
DOI:10.1021/jo048691v