1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane

Base Information

• Chemical Name: 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane
• CAS No.: 945215-10-1
• Molecular Formula: C₂₂H₂₅N₂PS
• Molecular Weight: 380.494
• Mol file: 945215-10-1.mol

Synonyms:1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane

Chemical Property of 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane

There total 2 articles about 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dichloro(thiophene-2-yl)phosphine (1726-72-3) + (+)-N,N'-Bis<(R)-1-phenylethyl>-1,2-ethylendiamin (76740-22-2) → 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane (945215-10-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.jorganchem.2007.03.008

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → 1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane (945215-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / Et₃N / acetonitrile / 15 h / 110 °C

2: 80 percent / Et₃N / tetrahydrofuran / 0.5 h / 20 °C

With triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.jorganchem.2007.03.008

Reference yield: 72.0%

1,3-bis[(1R)-1-phenylethyl]-2-(2-thienyl)-1,3,2-diazaphospholane (945215-10-1) + {Os3Rh(μ-H)3(CO)12} → [H2RhOs3(CO)11(μ,κ1-1,3-bis-(1-phenylethyl)-[1,3,2]diazaphospholidine-2-yl)]

Guidance literature:

In chloroform; byproducts: C4H4S; (Ar); using Schlenk techniques; stirring of soln. of H3RhOs3(CO)12 and 1,3-bis((1R)-1-phenylethyl)-2-(2-thienyl)-1,3,2-diazaphospholane in degassed CHCl3 at room temp. for 30 min and at 40°C for 30 min; monitoring by TLC; evapn. of solvent under reduced pressure, diluting with CH2Cl2 and hexane; chromy.; elem. anal.;

DOI:10.1016/j.jorganchem.2007.03.008

upstream raw materials:

dichloro(thiophene-2-yl)phosphine

(+)-N,N'-Bis<(R)-1-phenylethyl>-1,2-ethylendiamin

(R)-1-phenyl-ethyl-amine