(S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

Base Information

• Chemical Name: (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester
• CAS No.: 1026815-19-9
• Molecular Formula: C₂₇H₄₅N₃O₅S
• Molecular Weight: 523.737
• Mol file: 1026815-19-9.mol

Synonyms:(S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

Chemical Property of (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

There total 5 articles about (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester (1026815-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / Ambient temperature

3: 1 N aq. NaOH / methanol / Ambient temperature

4: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9800907

Reference yield:

N-(t-butoxycarbonyl)-isoleucine aldehyde (118171-79-2,141321-51-9,141321-54-2,87694-55-1) → (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester (1026815-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide

2: Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / Ambient temperature

3: 1 N aq. NaOH / methanol / Ambient temperature

4: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9800907

Reference yield:

(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentylamino)-3-phenyl-propionic acid methyl ester (150350-31-5) → (S)-2-{(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester (1026815-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / Ambient temperature

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9800907

upstream raw materials:

(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

(S)-2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentyl)-methyl-amino]-3-phenyl-propionic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

N-(t-butoxycarbonyl)-isoleucine aldehyde