N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester

Base Information

• Chemical Name: N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester
• CAS No.: 85541-33-9
• Molecular Formula: C₂₁H₃₂N₂O₆
• Molecular Weight: 408.495
• Mol file: 85541-33-9.mol

Synonyms:N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester

Chemical Property of N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester

There total 2 articles about N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Tyr(t-Bu)-OH (47375-34-8) + methoxycarbonylmethylamine (616-34-2) → N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester (85541-33-9)

Guidance literature:

With benzotriazol-1-ol; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/cn4000583

Reference yield:

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + N-t-butoxycarbonyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (30845-23-9) → N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester (85541-33-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at 0 ℃;

Reference yield: 100.0%

N-t-butoxycarbonyl-O-t-butyl-L-tyrosylglycine methyl ester (85541-33-9) → C20H30O5N2

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/ol990960u

upstream raw materials:

glycine ethyl ester hydrochloride

N-t-butoxycarbonyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt

Boc-Tyr(t-Bu)-OH

methoxycarbonylmethylamine

Downstream raw materials:

Boc-Tyr(O-t-Bu)-Glu-Gly-OH

Refernces

• 1、 Creighton,Zapf,Bu,Goodman. "Solid-phase synthesis of pyridones and pyridopyrazines as peptidomimetic scaffolds.". . p. 1407 - 1409. Retrieved 2008/02/09.