(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

Base Information

Chemical Name:(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine
CAS No.:449146-91-2
Molecular Formula:C₂₃H₂₇ClN₂O₄
Molecular Weight:430.931
Hs Code.:

Synonyms:(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

Suppliers and Price of (3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

Chemical Property:

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Technology Process of (3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

There total 1 articles about (3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261761-97-1
(3R,4R,5R)-1-N-Acetyl-3',4,5-tri-O-benzyl-4,5-dihydroxy-3-hydroxymethylhexahydropyridazine

: 449146-91-2
(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 7 h / 25 °C

1.2: 73 percent / CH₃ONa / methanol / 1 h

2.1: 65 percent / methanesulfonyl chloride; CsCl; pyridine / 4 h / 80 °C

With pyridine; cesium chloride; methanesulfonyl chloride;
DOI:10.1039/b200884j

Reference yield: 66.0%

: 449146-91-2
(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

: 449146-92-3
(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-methylhexahydropyridazine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 1.5h;
DOI:10.1039/b200884j

Reference yield:

: 449146-91-2
(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-chloromethylhexahydropyridazine

: 449146-83-2,193808-59-2,443649-15-8
(3R,4R,5R)-4,5-dihydroxy-3-methylhexahydropyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / n-Bu₃SnH; AIBN / toluene / 1.5 h / 110 °C

2: H₂; aq. HCl / 10percent Pd/C / methanol / 18 h / 20 °C / 760.05 Torr

3: 8 mg / aq. HCl / 24 h / 100 °C

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; 10percent Pd/C; In methanol; toluene;
DOI:10.1039/b200884j