Technology Process of S-2,4,6-trimethylphenyl 2-diazoethanethioate
There total 4 articles about S-2,4,6-trimethylphenyl 2-diazoethanethioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine; Methanesulfonyl azide;
In
water; acetonitrile;
at 25 ℃;
for 2.5h;
DOI:10.1021/jo000227c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 54 percent / zinc-mercury amalgam; sulfuric acid; hydrochloric acid / H2O / Heating
2.1: 96 percent / pyridine / CH2Cl2 / 2.17 h / 0 - 25 °C
3.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: tetrahydrofuran; hexane / 0.17 h / -78 °C
4.1: 1.01 g / triethylamine; methanesulfonyl azide / acetonitrile; H2O / 2.5 h / 25 °C
With
pyridine; hydrogenchloride; sulfuric acid; triethylamine; Methanesulfonyl azide; mercury; lithium hexamethyldisilazane; zinc;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
1.1: Reduction / 2.1: Acetylation / 3.1: Metallation / 3.2: Acylation / 4.1: Substitution;
DOI:10.1021/jo000227c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 96 percent / pyridine / CH2Cl2 / 2.17 h / 0 - 25 °C
2.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: tetrahydrofuran; hexane / 0.17 h / -78 °C
3.1: 1.01 g / triethylamine; methanesulfonyl azide / acetonitrile; H2O / 2.5 h / 25 °C
With
pyridine; triethylamine; Methanesulfonyl azide; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
1.1: Acetylation / 2.1: Metallation / 2.2: Acylation / 3.1: Substitution;
DOI:10.1021/jo000227c
