(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Base Information

Chemical Name:(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane
CAS No.:767288-14-2
Molecular Formula:C₁₅H₂₃NO₄S
Molecular Weight:313.418
Hs Code.:

Synonyms:(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Suppliers and Price of (5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Chemical Property:

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Technology Process of (5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

There total 5 articles about (5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 903517-50-0
(S)-4-aza-6-(tert-butyldimethylsilanyloxy)-5-isopropyl-4-(p-toluenesulfonyl)hexanal dimethyl acetal

: 767288-14-2
(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 36h;
DOI:10.1021/jo060495w

Reference yield:

: 139192-48-6
(S)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

: 767288-14-2
(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / dimethylformamide / 0 - 25 °C

2: 91 percent / Cs₂CO₃ / dimethylformamide / 96 h / 25 °C

3: 78 percent / HCl; water / tetrahydrofuran / 36 h / 20 °C

With 1H-imidazole; hydrogenchloride; water; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo060495w

Reference yield:

: 316363-67-4
(S)-O-(tert-butyldimethylsilyl)-N-(4-methylbenzenesulfonyl)-valinol

: 767288-14-2
(5S)-4-aza-1-hydroxy-5-isopropyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Cs₂CO₃ / dimethylformamide / 96 h / 25 °C

2: 78 percent / HCl; water / tetrahydrofuran / 36 h / 20 °C

With hydrogenchloride; water; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo060495w