N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

Base Information

Chemical Name:N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide
CAS No.:1335218-88-6
Molecular Formula:C₂₄H₂₀BrFN₂O₄S
Molecular Weight:531.402
Hs Code.:

Synonyms:N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

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Chemical Property of N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

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Technology Process of N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

There total 9 articles about N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335218-80-8
2-(9-amino-7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-yl)ethanol

: 532-55-8
Benzoyl isothiocyanate

: 1335218-88-6
N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1335218-39-7
5-bromo-2-(2-fluoro-4-methoxyphenoxy)benzoic acid

: 1335218-88-6
N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate; trifluoroacetic acid; trifluoroacetic anhydride / 4 h / 20 °C / Industrial scale; Large scale

2.1: bromine; zinc / diethyl ether / 2.33 h / 20 °C / Reflux

2.2: 3 h / Reflux

2.3: 2 h / 20 °C

3.1: trimethylsilylazide; boron trifluoride diethyl etherate / toluene / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

5.1: tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; trimethylsilylazide; boron trifluoride diethyl etherate; bromine; trifluoroacetic acid; trifluoroacetic anhydride; zinc; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

: 1335218-40-0
7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one

: 1335218-88-6
N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; zinc / diethyl ether / 2.33 h / 20 °C / Reflux

1.2: 3 h / Reflux

1.3: 2 h / 20 °C

2.1: trimethylsilylazide; boron trifluoride diethyl etherate / toluene / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.1: tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; trimethylsilylazide; boron trifluoride diethyl etherate; bromine; zinc; In tetrahydrofuran; diethyl ether; toluene;