methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Base Information

Chemical Name:methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate
CAS No.:179420-61-2
Molecular Formula:C₂₄H₂₄F₂N₂O₄
Molecular Weight:442.462
Hs Code.:

Synonyms:methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

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Chemical Property of methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

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Technology Process of methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

There total 11 articles about methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 179421-06-8
methyl 4-(2,5-difluoro-3-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

: 4-(2-methyl-1H-imidazol-1-yl)benzyl chloride hydrochloride

: 179420-61-2
methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.965

Reference yield:

: 179421-01-3
2,5-difluoro-3-methoxybenzaldehyde

: 179420-61-2
methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 95 percent / NaBH₄ / ethanol / 0.5 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

3.1: 5.91 g / dimethylsulfoxide / 2 h

4.1: KOH / ethane-1,2-diol / 1 h / 120 °C

5.1: 3.80 g / H₂SO₄ / 1 h / Heating

6.1: NaH; 15-crown-5 / dimethylformamide / 0.67 h / 20 °C

6.2: NaI / dimethylformamide / 10.5 h

7.1: BBr₃ / CH₂Cl₂ / 23 h

8.1: 49 percent / K₂CO₃ / dimethylformamide

With potassium hydroxide; sodium tetrahydroborate; 15-crown-5; sulfuric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; In ethanol; dichloromethane; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.965

Reference yield:

: 179421-02-4
2,5-difluoro-3-methoxybenzyl alcohol

: 179420-61-2
methyl 4-{2,5-difluoro-3-[4-(2-methyl-1H-imidazol-1-yl)]benzyloxyphenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

2.1: 5.91 g / dimethylsulfoxide / 2 h

3.1: KOH / ethane-1,2-diol / 1 h / 120 °C

4.1: 3.80 g / H₂SO₄ / 1 h / Heating

5.1: NaH; 15-crown-5 / dimethylformamide / 0.67 h / 20 °C

5.2: NaI / dimethylformamide / 10.5 h

6.1: BBr₃ / CH₂Cl₂ / 23 h

7.1: 49 percent / K₂CO₃ / dimethylformamide

With potassium hydroxide; 15-crown-5; sulfuric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; In dichloromethane; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.965