methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate

Base Information

• Chemical Name: methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate
• CAS No.: 1561966-61-7
• Molecular Formula: C₂₄H₃₅N₃O₄
• Molecular Weight: 429.56
• Mol file: 1561966-61-7.mol

Synonyms:methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate

Chemical Property of methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate

There total 4 articles about methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)boronic acid (1561964-16-6) + methyl 5-bromo-1H-1,2,4-triazole-3-carboxylate (704911-47-7) → methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate (1561966-61-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

Reference yield:

5-bromo-1-(tert-butyl)-2-(methoxymethoxy)-3-methylbenzene (1561964-14-4) → methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate (1561966-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C

1.2: -78 - 20 °C

1.3: 2 h / 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

4-bromo-2-(tert-butyl)-6-methylphenol (25476-59-9) → methyl 5-(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate (1561966-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / dichloromethane / 0.42 h / 0 °C

1.2: 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C

2.2: -78 - 20 °C

2.3: 2 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(3-(tert-butyl)-4-(methoxymethoxy)-5-methylphenyl)boronic acid

methyl 5-bromo-1H-1,2,4-triazole-3-carboxylate

4-bromo-2-(tert-butyl)-6-methylphenol

2-tert-Butyl-6-methylphenol

Downstream raw materials:

methyl 5-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxylate

5-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)-1-(cyclohexylmethyl)-1H-1,2,4-triazole-3-carboxamide