ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

Base Information

Chemical Name:ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide
CAS No.:1581258-84-5
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

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Chemical Property of ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

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Technology Process of ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

There total 5 articles about ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1581259-07-5
ethyl 2-[N,N-bis(3,5-dimethylphenyl)sulfamoyl]-2-diazoacetate

: 1581258-84-5
ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

Guidance literature:: With rhodium (II) octanoate dimer; In 1,2-dichloro-ethane; for 2h; Inert atmosphere; Reflux;
DOI:10.1039/c4cc00250d

Reference yield:

: 1581259-53-1
ethyl 2-[N,N-bis(3,5-dimethylphenyl)sulfamoyl]acetate

: 1581258-84-5
ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.27 h / 0 °C / Sealed tube

2: rhodium (II) octanoate dimer / 1,2-dichloro-ethane / 2 h / Inert atmosphere; Reflux

With 4-toluenesulfonyl azide; rhodium (II) octanoate dimer; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1039/c4cc00250d

Reference yield:

: 5369-25-5
bis-(3,5-dimethylphenyl)-amine

: 1581258-84-5
ethyl 4,6-dimethyl-1-(3,5-dimethylphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 24 h / 20 °C

2: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.27 h / 0 °C / Sealed tube

3: rhodium (II) octanoate dimer / 1,2-dichloro-ethane / 2 h / Inert atmosphere; Reflux

With 4-toluenesulfonyl azide; rhodium (II) octanoate dimer; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1039/c4cc00250d