phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol

Base Information

• Chemical Name: phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol
• CAS No.: 284687-71-4
• Molecular Formula: C₃₉H₅₄N₂O₉
• Molecular Weight: 694.866
• Mol file: 284687-71-4.mol

Synonyms:phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol

Chemical Property of phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol

There total 2 articles about phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 13-(4-bromophenyl)-1,4,7,10-tetraoxa-13-azacyclopentadecane (169784-42-3) → phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol (284687-71-4)

Guidance literature:

13-(4-bromophenyl)-1,4,7,10-tetraoxa-13-azacyclopentadecane; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

benzoic acid methyl ester; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;

DOI:10.1021/ja9943694

Reference yield:

13-phenyl-1,4,7,10-tetraoxa-13-aza-cyclopentadecane (66750-10-5) → phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol (284687-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CCl₄ / 3 h / Heating

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; In tetrahydrofuran; tetrachloromethane; 1.1: Bromination / 2.1: Metallation / 2.2: Condensation;

DOI:10.1021/ja9943694

Reference yield:

potassium cyanide (151-50-8) + phenyl-bis-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-methanol (284687-71-4) → bis[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)phenyl]phenylmethanenitrile (188345-46-2)

Guidance literature:

With hydrogenchloride; In dimethyl sulfoxide; at 60 ℃; for 0.166667h;

DOI:10.1021/ja9943694

upstream raw materials:

benzoic acid methyl ester

13-(4-bromophenyl)-1,4,7,10-tetraoxa-13-azacyclopentadecane

13-phenyl-1,4,7,10-tetraoxa-13-aza-cyclopentadecane

Downstream raw materials:

bis[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)phenyl]phenylmethanenitrile