N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide

Base Information

• Chemical Name: N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide
• CAS No.: 1191988-25-6
• Molecular Formula: C₂₃H₂₂FN₃O₂S
• Molecular Weight: 423.511

Synonyms:N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide

Chemical Property of N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide

Chemical Property:

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Technology Process of N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide

There total 1 articles about N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-[(cyclopropylamino)carbonyl]-3'-fluoro-2'-methyl-4-biphenylcarboxylic acid + [(2-methyl-1,3-thiazol-4-yl)-methyl]amine (103694-26-4) → N3-cyclopropyl-5-fluoro-6-methyl-N4'-[(2-methyl-1,3-thiazol-4-yl)methyl]-3,4'-biphenyldicarboxamide (1191988-25-6)

Guidance literature:

5'-[(cyclopropylamino)carbonyl]-3'-fluoro-2'-methyl-4-biphenylcarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

[(2-methyl-1,3-thiazol-4-yl)-methyl]amine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm9004779

upstream raw materials:

[(2-methyl-1,3-thiazol-4-yl)-methyl]amine

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