ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

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Chemical Name:ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate
CAS No.:403599-96-2
Molecular Formula:C₂₃H₂₇N₃O₄
Molecular Weight:409.485
Hs Code.:

Synonyms:ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

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Chemical Property of ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

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Technology Process of ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

There total 3 articles about ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3173-56-6
benzyl isothiocyanate

: 403599-92-8
ethyl 3-(8-amino-2,3,4,5-tetrahydrobenz[b]azepin-1-yl)-3-oxopropanoate

: 403599-96-2
ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

Guidance literature:: In acetonitrile; at 20 ℃; for 12h;
DOI:10.1248/cpb.49.1420

Reference yield:

: 17422-54-7
8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine

: 403599-96-2
ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / Et₃N / CHCl₃ / 14 h / 20 °C

2: 100 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

3: 84 percent / acetonitrile / 12 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; chloroform; acetonitrile;
DOI:10.1248/cpb.49.1420

Reference yield:

: 229636-64-0
ethyl 3-(8-nitro-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)-3-oxopropanoate

: 403599-96-2
ethyl 3-[6-(3-benzylureido)-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl]-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

2: 84 percent / acetonitrile / 12 h / 20 °C

With hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1248/cpb.49.1420