(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

Base Information

Chemical Name:(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol
CAS No.:474380-58-0
Molecular Formula:C₁₉H₃₆O
Molecular Weight:280.494
Hs Code.:

Synonyms:(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

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Chemical Property of (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

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Technology Process of (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

There total 5 articles about (E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 71570-23-5
(E)-1-iodo-2-methyl-1-heptene

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 474380-45-5
(E)-(S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

: 474380-58-0
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

Guidance literature:: (E)-1-iodo-2-methyl-1-heptene; With tert.-butyl lithium; In diethyl ether; at -78 - 20 ℃; for 1h;

With trimethylaluminum; In diethyl ether; hexane; at 25 ℃;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; In diethyl ether; hexane; at -78 ℃;
DOI:10.1021/ja046084j

Reference yield: 58.0%

: 628-71-7
1-Heptyne

: 75-24-1
trimethylaluminum

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 474380-45-5
(E)-(S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

: 474380-58-0
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

Guidance literature:: 1-Heptyne; trimethylaluminum; zirconocene dichloride; In dichloromethane; at -30 - 20 ℃;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; In tetrahydrofuran; dichloromethane; at -30 - 20 ℃; Further stages.;
DOI:10.1021/jo800817p

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 474380-58-0
(E)-(R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-oct-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: tetrahydrofuran; hexane / 10 h / 20 °C

2.1: 3.10 g / aq. HCl / CHCl₃ / 4 h / 20 °C

3.1: t-BuLi / diethyl ether / 1 h / -78 - 20 °C

3.2: trimethylaluminum / diethyl ether; hexane / 25 °C

3.3: diethyl ether; hexane / -78 °C

With hydrogenchloride; n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; hexane; chloroform;
DOI:10.1021/ja046084j