Technology Process of C45H60N4O9
There total 7 articles about C45H60N4O9 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S)-2-(benzyloxycarbonylamino)-6-(N-(benzyloxy)formamido) hexanoic acid;
With
2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; toluene;
for 1h;
C23H36N2O4;
With
dmap;
In
tetrahydrofuran; toluene;
at 20 - 110 ℃;
for 16.5h;
DOI:10.1016/j.bmcl.2011.01.084
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 h / 20 °C
2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 36 h / 20 °C
3.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; toluene / 1 h
3.2: 16.5 h / 20 - 110 °C
With
2,4,6-trichlorobenzoyl chloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; water; toluene;
3.1: Yamaguchi reaction / 3.2: Yamaguchi reaction;
DOI:10.1016/j.bmcl.2011.01.084
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Reflux
2.1: [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); hydrogen bromide; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / methanol; acetone / 18 h / 55 °C / 760.05 Torr
3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 h / 20 °C
5.1: sodium hydrogencarbonate / tetrahydrofuran; water / 36 h / 20 °C
6.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; toluene / 1 h
6.2: 16.5 h / 20 - 110 °C
With
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 2,4,6-trichlorobenzoyl chloride; water; hydrogen bromide; hydrogen; sodium hydrogencarbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide;
In
tetrahydrofuran; methanol; water; acetone; toluene;
6.1: Yamaguchi reaction / 6.2: Yamaguchi reaction;
DOI:10.1016/j.bmcl.2011.01.084
