(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

Base Information

Chemical Name:(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid
CAS No.:96846-19-4
Molecular Formula:2C₂HF₃O₂*C₁₉H₂₃N₉O₃
Molecular Weight:653.498
Hs Code.:

Synonyms:(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

There total 6 articles about (S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 100430-92-0
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^γ-(tert-butyloxycarbonyl)-L-2,4-diaminobutyric acid

: 76-05-1
trifluoroacetic acid

: 96846-19-4
(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: at 0 - 5 ℃; for 1h;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-95-3
N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N⁴-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminobutanoic acid

: 96846-19-4
(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / (i-Pr)2NEt / dimethylformamide / 120 h / 20 - 25 °C

2: 97 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr / Ambient temperature

3: 79 percent / N,N-dimethyl-acetamide / 144 h

4: 93 percent / NaOH / ethanol / 4 h / 20 - 25 °C

5: 94 percent / 1 h / 0 - 5 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-91-9
ethyl N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N⁴-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminobutanoate

: 96846-19-4
(S)-4-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr / Ambient temperature

2: 79 percent / N,N-dimethyl-acetamide / 144 h

3: 93 percent / NaOH / ethanol / 4 h / 20 - 25 °C

4: 94 percent / 1 h / 0 - 5 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00146a008