ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

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Chemical Name:ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide
CAS No.:911132-35-9
Molecular Formula:C₂₁H₁₈N₂O₅S
Molecular Weight:410.45
Hs Code.:

Synonyms:ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

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Chemical Property of ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

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Technology Process of ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

There total 2 articles about ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 874-60-2
4-methyl-benzoyl chloride

: 160146-64-5
ethyl 10,11-dihydropyrrolo<1,2-b><1,2,5>benzothiadiazepine-11-carboxylate 5,5-dioxide

: 911132-35-9
ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

Guidance literature:: With sodium hydrogencarbonate; In 1.3-chlorobromopropane; Heating / reflux;

Reference yield:

: 54254-41-0
1-(2-aminobenzenesulfonyl)-1H-pyrrole

: 911132-35-9
ethyl 10,11-dihydro-10-(4-methyl-benzoyl)-pyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-carboxylate 5,5-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / 4-toluenesulfonic acid monohydrate / ethanol / Heating

2: 40 percent / NaHCO₃; 1-bromo-3-chloropropane / Heating

With p-toluenesulfonic acid monohydrate; sodium hydrogencarbonate; 1.3-chlorobromopropane; In ethanol; 1: Pictet-Spengler reaction;
DOI:10.1021/jm0602716