N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine

Base Information

• Chemical Name: N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine
• CAS No.: 1537866-83-3
• Molecular Formula: C₂₅H₂₀F₂N₆
• Molecular Weight: 442.471

Synonyms:N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine

Chemical Property of N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine

Chemical Property:

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Technology Process of N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine

There total 4 articles about N⁴-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N²-(2,6-difluorophenyl)quinazolin-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(3-allyl-2-methyl-3H-benzimidazol-5-yl)-(2-chloroquinazolin-4-yl)amine (1434623-48-9) + 2,6-difluoroaniline (5509-65-9) → N4-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N2-(2,6-difluorophenyl)quinazolin-2,4-diamine (1537866-83-3)

Guidance literature:

In isopropyl alcohol; Reflux;

DOI:10.1016/j.bmcl.2013.12.005

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → N4-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N2-(2,6-difluorophenyl)quinazolin-2,4-diamine (1537866-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 6 h / 160 °C

2: triethylamine; trichlorophosphate / 7 h / Reflux

3: isopropyl alcohol / 20 °C

4: isopropyl alcohol / Reflux

With triethylamine; trichlorophosphate; In isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.005

Reference yield:

1,2,3,4-tetrahydro-quinazoline-2,4-dione (86-96-4) → N4-(3-allyl-2-methyl-3H-benzimidazol-5-yl)-N2-(2,6-difluorophenyl)quinazolin-2,4-diamine (1537866-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; trichlorophosphate / 7 h / Reflux

2: isopropyl alcohol / 20 °C

3: isopropyl alcohol / Reflux

With triethylamine; trichlorophosphate; In isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.005

upstream raw materials:

anthranilic acid

(3-allyl-2-methyl-3H-benzimidazol-5-yl)-(2-chloroquinazolin-4-yl)amine

2,6-difluoroaniline

1,2,3,4-tetrahydro-quinazoline-2,4-dione

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