Technology Process of ddTAC-CHO
There total 8 articles about ddTAC-CHO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-amino-3-(2-methoxyethoxy)benzaldehyde;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 1h;
Inert atmosphere;
C28H41N3O6;
In
water; acetonitrile;
at 0 - 25 ℃;
for 12.5h;
Inert atmosphere;
DOI:10.1002/ejoc.201001450
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate; sodium iodide / acetone / 16 h / Inert atmosphere
2.1: lithium / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere
2.2: 0.33 h / -78 °C / Inert atmosphere
2.3: 4.5 h / -78 - 0 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C / Inert atmosphere
4.2: 12.5 h / 0 - 25 °C / Inert atmosphere
With
hydrogenchloride; lithium; sodium carbonate; trifluoroacetic acid; sodium iodide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; acetone;
1.1: Finkelstein modified Williamson ether synthesis;
DOI:10.1002/ejoc.201001450
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide; sodium hydroxide / N,N-dimethyl acetamide / 0.2 h / 105 °C / Inert atmosphere; Microwave irradiation
2.1: sodium carbonate; sodium iodide / acetone / 16 h / Inert atmosphere
3.1: lithium / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere
3.2: 0.33 h / -78 °C / Inert atmosphere
3.3: 4.5 h / -78 - 0 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
5.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C / Inert atmosphere
5.2: 12.5 h / 0 - 25 °C / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; lithium; sodium carbonate; trifluoroacetic acid; sodium iodide; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; acetone;
1.1: Buchwald-Hartwig reaction / 2.1: Finkelstein modified Williamson ether synthesis;
DOI:10.1002/ejoc.201001450
