Technology Process of 6-Bromomethyl-1,1-dimethyl-1,2,3,4-tetrahydro-naphthalene
There total 1 articles about 6-Bromomethyl-1,1-dimethyl-1,2,3,4-tetrahydro-naphthalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 72 percent / AlCl3 / 2.5 h / 90 - 100 °C
2: 65 percent / AlCl3, Br2 / CH2Cl2 / 0.5 h / 80 °C
3: 65 percent / CF3COOH, triethylsilane / 8 h / 0 - 20 °C
4: 1.) n-BuLi / 1.) ether, hexane, RT, 40 min, 2.) ether, hexane, 0 def C, 20 min
5: NaBH4 / methanol / 0.5 h / 0 °C
6: CHBr3, Ph3P / CH2Cl2 / 0.25 h / 0 °C
With
triethylsilane; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; Bromoform; bromine; triphenylphosphine; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1021/jm970704s
- Guidance literature:
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Multi-step reaction with 10 steps
1: 32 percent / fuming HNO3, AcOH, Ac2O / 0.33 h / 0 °C
2: 97 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature
3: conc. aq. HCl / acetic acid / 14 h / Heating
4: SOCl2 / 20 h / Ambient temperature
5: CH2Cl2 / 18 h / Ambient temperature
6: LiBH4 / tetrahydrofuran / 19 h / 0 - 20 °C
7: 92 percent / H2 / 10percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature
8: acetic anhydride / tetrahydrofuran / 2 h / 60 - 70 °C
9: BH3 / tetrahydrofuran / 3 h / 0 °C
10: 82 percent / 2,6-lutidine / 1,2-dichloro-ethane / 48 h / Heating
With
2,6-dimethylpyridine; hydrogenchloride; lithium borohydride; thionyl chloride; borane; hydrogen; nitric acid; acetic anhydride; sodium hydride; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970704s