tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

Base Information

Chemical Name:tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate
CAS No.:1388892-85-0
Molecular Formula:C₁₈H₂₄BrN₃O₃S
Molecular Weight:442.377
Hs Code.:

Synonyms:tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

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Chemical Property of tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

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Technology Process of tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

There total 1 articles about tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 400899-99-2
tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate

: 814918-95-1
5-bromo-4-chlorothieno[2,3-d]pyrimidine

: 1388892-85-0
tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

Guidance literature:: tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

5-bromo-4-chlorothieno[2,3-d]pyrimidine; In tetrahydrofuran; mineral oil; at 60 ℃; for 4h; Inert atmosphere;

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 1388892-85-0
tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

: 1388892-88-3
tert-butyl ((1r,4r)-4-{[5-(benzofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy}cyclohexyl)(methyl)carbamate

Guidance literature:: With sodium carbonate; triphenylphosphine; palladium diacetate; In water; toluene; Inert atmosphere; Reflux; sealed tube;

Reference yield:

: 1388892-85-0
tert-butyl {(1r,4r)-4-[(5-bromothieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(methyl)carbamate

: 1388892-83-8
4-{[5-(1-benzofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy}-N,N-dimethylcyclohexan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / toluene; water / Inert atmosphere; Reflux; sealed tube

2.1: hydrogenchloride / dichloromethane; water / 0 - 20 °C

2.2: pH 9

3.1: methanol / 1 h / 20 °C

3.2: 1 h / 20 °C

With hydrogenchloride; sodium carbonate; triphenylphosphine; palladium diacetate; In methanol; dichloromethane; water; toluene;