1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon

Base Information

• Chemical Name: 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon
• CAS No.: 68753-36-6
• Molecular Formula: C₂₅H₂₄N₂O₆
• Molecular Weight: 448.475
• Mol file: 68753-36-6.mol

Synonyms:1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon

Chemical Property of 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon

There total 3 articles about 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.5%

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 2-trimethylsilyloxypyrimidine (52523-22-5) → 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon (68753-36-6) + 1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2(1H)-pyrimidinone (68753-37-7)

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; at 35 ℃; for 3h; Solvent;

DOI:10.1016/j.carres.2014.03.018

Reference yield: 30.0%

methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose (4330-34-1) + 2-trimethylsilyloxypyrimidine (52523-22-5) → 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon (68753-36-6)

Guidance literature:

trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1002/hlca.19850680221

Reference yield:

→ 1-<2'-Desoxy-3',5'-di-O-(p-toluoyl)-β-D-ribofuranosyl>-2(1H)-pyrimidinon (68753-36-6)

Guidance literature:

Pyrimidinol I, Furanosylchlorid 2;

upstream raw materials:

methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

2-trimethylsilyloxypyrimidine

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

Downstream raw materials:

1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2(1H)-pyrimidinone

1-(2'-Desoxy-5'-O-dimethoxytrityl-β-D-ribofuranosyl)-2(1H)-pyrimidinon

2-Desoxy-β-D-ribofuranosyl-2(1H)-pyrimidinon-3'-<(2-chlorophenyl)-(2-cyanoaethyl)-phosphat>

1-β-D-deoxyribofuranosyl-1,2-dihydropyrimidin-2-one