2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

Base Information

Chemical Name:2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide
CAS No.:1557245-56-3
Molecular Formula:C₁₅H₁₉N₃O₂S
Molecular Weight:305.401
Hs Code.:

Synonyms:2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

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Chemical Property of 2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

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Technology Process of 2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

There total 6 articles about 2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((4-nitro-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

: 1557245-56-3
2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 3h; under 760.051 Torr;
DOI:10.1021/jm501998m

Reference yield:

: 4988-34-5
tetrahydro-2H-thiopyran-1-oxide

: 1557245-56-3
2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - -20 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 25 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

With n-butyllithium; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 2.1: |Mitsunobu Displacement;
DOI:10.1021/jm501998m

Reference yield:

: 261352-96-9
2-(hydroxy(phenyl)methyl)tetrahydro-2H-thiopyran-1-oxide

: 1557245-56-3
2-((4-amino-1H-pyrazol-1-yl)(phenyl)methyl)tetrahydro-2H-thiopyran-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 25 °C

3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1: |Mitsunobu Displacement;
DOI:10.1021/jm501998m