2-(diethoxyphosphoryl)phenyloxymethylbenzene

Base Information

• Chemical Name: 2-(diethoxyphosphoryl)phenyloxymethylbenzene
• CAS No.: 252554-76-0
• Molecular Formula: C₁₇H₂₁O₄P
• Molecular Weight: 320.325
• Mol file: 252554-76-0.mol

Synonyms:2-(diethoxyphosphoryl)phenyloxymethylbenzene

Chemical Property of 2-(diethoxyphosphoryl)phenyloxymethylbenzene

Chemical Property:

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Technology Process of 2-(diethoxyphosphoryl)phenyloxymethylbenzene

There total 1 articles about 2-(diethoxyphosphoryl)phenyloxymethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromophenyl benzyl ether (31575-75-4) + phosphonic acid diethyl ester (762-04-9) → 2-(diethoxyphosphoryl)phenyloxymethylbenzene (252554-76-0)

Guidance literature:

With palladium diacetate; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; In dimethyl sulfoxide; at 100 ℃; for 12h;

DOI:10.1021/ja992493h

Reference yield: 17.0%

2-(diethoxyphosphoryl)phenyloxymethylbenzene (252554-76-0) → benzyl 2-(phosphino)phenyl ether (252554-77-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 40 ℃; for 3h;

DOI:10.1021/jo062044h

Reference yield:

2-(diethoxyphosphoryl)phenyloxymethylbenzene (252554-76-0) → 2-[(2R,5R)-2,5-dimethylphospholano]phenyloxymethylbenzene

Guidance literature:

Multi-step reaction with 2 steps

1: 17 percent / LiAlH₄ / diethyl ether / 3 h / 40 °C

2: 58 percent / KH / tetrahydrofuran / 4 h / 20 °C

With lithium aluminium tetrahydride; potassium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo062044h

upstream raw materials:

2-bromophenyl benzyl ether

phosphonic acid diethyl ester

Downstream raw materials:

benzyl 2-(phosphino)phenyl ether

Refernces