1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

Base Information

Chemical Name:1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one
CAS No.:1375098-77-3
Molecular Formula:C₂₆H₂₄FNO₃
Molecular Weight:417.48
Hs Code.:

Synonyms:1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Property of 1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

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Technology Process of 1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

There total 6 articles about 1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375098-76-2
N-([1,1'-biphenyl]-3-ylmethyl)-N-(1-(4-fluoro-2,6-dimethoxyphenyl)but-3-en-1-yl)acrylamide

: 1375098-77-3
1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With titanium(IV) isopropylate; Grubbs catalyst first generation; In dichloromethane; at 50 ℃; for 21h; Inert atmosphere; Reflux;

Reference yield:

: 139549-11-4
4-fluoro-2,6-dimethoxybenzaldehyde

: 1375098-77-3
1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 75 °C / Inert atmosphere

2: diethyl ether; tetrahydrofuran / 0.5 h / -50 - 0 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

5: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: titanium(IV) isopropylate / Grubbs catalyst first generation / dichloromethane / 21 h / 50 °C / Inert atmosphere; Reflux

With titanium(IV) isopropylate; hydrogenchloride; dmap; titanium(IV) tetraethanolate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1375098-72-8
N-(4-fluoro-2,6-dimethoxybenzylidene)-2-methylpropane-2-sulfinamide

: 1375098-77-3
1-([1,1'-biphenyl]-3-ylmethyl)-6-(4-fluoro-2,6-dimethoxyphenyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether; tetrahydrofuran / 0.5 h / -50 - 0 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

4: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: titanium(IV) isopropylate / Grubbs catalyst first generation / dichloromethane / 21 h / 50 °C / Inert atmosphere; Reflux

With titanium(IV) isopropylate; hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;