(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

Base Information

Chemical Name:(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate
CAS No.:841275-70-5
Molecular Formula:C₂₁H₂₅N₆O₆P
Molecular Weight:488.44
Hs Code.:

Synonyms:(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

Chemical Property:

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Technology Process of (Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

There total 7 articles about (Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-{[2-[1-(6-Amino-purin-9-yl)-meth-(Z)-ylidene]-1-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-phenoxy-phosphorylamino}-propionic acid methyl ester

: 841275-70-5
(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

Guidance literature:: With acetic acid; at 20 ℃;
DOI:10.1021/jm040149b

Reference yield:

: 142629-80-9
phenyl methoxyalaninyl phosphorochloridate

: 841275-70-5
(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methylimidazole; pyridine / tetrahydrofuran / 20 °C

2: 550 mg / aq. AcOH / 20 °C

With pyridine; 1-methyl-1H-imidazole; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm040149b

Reference yield:

: 632325-65-6
ZSM-I-32-F

: 841275-70-5
(Z)-9-{[(2,2-hydroxymethyl)cyclopropylidene]methyl}adenine (methylphenylphosphoryl) P-N-L-alaninate

Guidance literature:: Multi-step reaction with 6 steps

1: methanesulfonic acid / dimethylformamide / 20 °C

2: 2.95 g / aq. AcOH / 10 h / 20 °C

3: methanesulfonic acid / dimethylformamide / 20 °C

4: 2.3 g / NH₄OH / methanol / 40 - 50 °C

5: 1-methylimidazole; pyridine / tetrahydrofuran / 20 °C

6: 550 mg / aq. AcOH / 20 °C

With pyridine; 1-methyl-1H-imidazole; ammonium hydroxide; methanesulfonic acid; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm040149b