methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

Base Information

Chemical Name:methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate
CAS No.:114822-88-7
Molecular Formula:C₂₅H₂₆ClN₃O₅
Molecular Weight:483.952
Hs Code.:

Synonyms:methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

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Chemical Property of methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

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Technology Process of methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

There total 8 articles about methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 85-44-9
phthalic anhydride

: 114772-05-3
methyl 2-butyl-4-chloro-1-(4-aminobenzyl)-imidazole-5-acetate

: 114822-88-7
methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

Guidance literature:: In chloroform; for 24h; Ambient temperature;
DOI:10.1021/jm00167a007

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 114822-88-7
methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / CHCl₃ / 2 h / 0 - 20 °C

2: dimethylsulfoxide

3: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

4: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

5: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

6: 86 percent / CHCl₃ / 24 h / Ambient temperature

With hydrogenchloride; thionyl chloride; iron; acetic acid; In 1,4-dioxane; methanol; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00167a007

Reference yield:

: 125665-56-7
2-Butyl-4-chloro-5-chloromethyl-1-(4-nitro-benzyl)-1H-imidazole

: 114822-88-7
methyl 2-n-butyl-1-<<4-(2-carboxybenzamido)phenyl>methyl>-4-chloroimidazole-5-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfoxide

2: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

3: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

4: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

5: 86 percent / CHCl₃ / 24 h / Ambient temperature

With hydrogenchloride; iron; acetic acid; In 1,4-dioxane; methanol; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00167a007