methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

Base Information

Chemical Name:methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate
CAS No.:1429313-08-5
Molecular Formula:C₂₃H₂₈N₄O₇
Molecular Weight:472.498
Hs Code.:

Synonyms:methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

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Chemical Property of methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

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Technology Process of methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

There total 11 articles about methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1429313-07-4
methyl 4-[5-(2,2,3,3,13,13-hexamethyl-11-oxo-4,7,12-trioxa-10-aza-3-silatetradecan-10-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-2-hydroxybenzoate

: 1429313-08-5
methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2020.112770

Reference yield:

: 1429313-06-3
tert-butyl N-{3-bromopyrazolo[1,5-a]pyrimidin-5-yl}-N-(2-{2-[(tert-butyldimethylsilyl)oxy]ethoxy}ethyl)carbamate

: 1429313-08-5
methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / 1,4-dioxane / 1 h / 110 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 960613-96-1
3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine

: 1429313-08-5
methyl 4-(5-{[(tert-butoxy)carbonyl][2-(2-hydroxyethoxy)ethyl]amino}pyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / Reflux

2: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3: triethylamine; dmap / tetrahydrofuran / 3 h / Reflux

4: potassium phosphate / 1,4-dioxane / 1 h / 110 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With dmap; potassium phosphate; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;