2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Chemical Name:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone
CAS No.:1380426-84-5
Molecular Formula:C₂₅H₂₁ClF₃N₅O₃
Molecular Weight:531.922
Hs Code.:

Synonyms:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Chemical Property of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Technology Process of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

There total 4 articles about 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.6%

: 1380429-37-7
5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-(nitroamino)-4(1H)-pyrimidinone

: 1380429-35-5
2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)ethanamine

: 1380426-84-5
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: In ethanol; at 100 ℃; Microwave irradiation;

Reference yield:

: 516481-95-1
4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde

: 1380426-84-5
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate; acetic acid / 3 h / 120 °C

2: sodium tetrahydroborate; (+/-)-2-pentanol; silica gel / chloroform / 3 h / 20 °C

3: methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate / 0 - 20 °C

4: ethanol / 100 °C / Microwave irradiation

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; (+/-)-2-pentanol; ammonium acetate; silica gel; acetic acid; In ethanol; chloroform;

Reference yield:

: 1380429-33-3
(E)-1-chloro-4-(4-(2-nitrovinyl)phenoxy)-2-(trifluoromethyl)benzene

: 1380426-84-5
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]amino}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; (+/-)-2-pentanol; silica gel / chloroform / 3 h / 20 °C

2: methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate / 0 - 20 °C

3: ethanol / 100 °C / Microwave irradiation

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; (+/-)-2-pentanol; silica gel; In ethanol; chloroform;