methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

Base Information

• Chemical Name: methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate
• CAS No.: 1451740-24-1
• Molecular Formula: C₂₈H₂₅N₃O₇
• Molecular Weight: 515.522

Synonyms:methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

Chemical Property of methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

Chemical Property:

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Technology Process of methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

There total 5 articles about methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C29H28O10S → methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate (1451740-24-1)

Guidance literature:

With sodium azide; In acetonitrile; at 80 ℃; for 15h; Reflux;

DOI:10.1021/acs.jmedchem.9b00963

Reference yield: 57.0%

→ methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate (1451740-24-1)

Guidance literature:

With sodium azide; In acetonitrile; at 80 ℃; for 15h;

Reference yield:

3-(benzyloxy)-2-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)-4H-chromen-4-one (1451740-26-3) → methyl 3-(((2-(4-(2-(2-azidoethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate (1451740-24-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; palladium on activated charcoal / tetrahydrofuran; methanol / 14 h / 20 °C

2: potassium carbonate / acetone / 12 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: sodium azide / acetonitrile / 15 h / 80 °C / Reflux

With sodium azide; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;

DOI:10.1021/acs.jmedchem.9b00963

upstream raw materials:

methyl 3-(((2-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

3-(benzyloxy)-2-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)-4H-chromen-4-one

3-hydroxy-2-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)-4H-chromen-4-one

Downstream raw materials:

methyl 3-(((2-(4-(2-(2-(4-(4-(4-(6-methyl-4-oxo-4H-chromen-2-yl)phenoxy)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

methyl 3-(((4-oxo-2-(4-(2-(2-(4-(4-((4-oxo-2-phenyl-4H-chromen-7-yl)oxy)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)phenyl)-4H-chromen-3-yl)oxy)methyl)benzoate

methyl 3-(((4-oxo-2-(4-(2-(2-(4-((2-((4-oxo-2-phenyl-4H-chromen-7-yl)oxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)phenyl)-4H-chromen-3-yl)oxy)methyl)benzoate

dimethyl 3,3'-(((2,2'-((((((4,4'-((benzylazanediyl)bis(methylene))bis(1H-1,2,3-triazole-4,1-diyl))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(4,1-phenylene))bis(4-oxo-4H-chromene-3,2-diyl))bis(oxy))bis(methylene))dibenzoate

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