(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Base Information

Chemical Name:(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate
CAS No.:1402852-72-5
Molecular Formula:C₂₇H₂₅Cl₂F₆NO₆
Molecular Weight:644.395
Hs Code.:

Synonyms:(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Suppliers and Price of (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

There total 3 articles about (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402852-66-7
(Z)-4-(cyclohexylmethylene)-2-(3,4-dichlorophenyl)oxazol-5(4H)-one

: 104883-33-2
malonic acid di(2,2,2-trifluoroethyl ester)

: 1402852-72-5
(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Guidance literature:: With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 20 ℃; for 16.8333h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja309003x DOI:10.1021/ja309003x

Reference yield:

: 17321-80-1
2-(3,4-dichlorobenzamido)acetic acid

: 1402852-72-5
(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 1 h / Inert atmosphere

2: aluminum oxide / dichloromethane / 2 h / Inert atmosphere

3: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium(0) chloroform complex / toluene / 16.83 h / 20 °C / Inert atmosphere

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); aluminum oxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; toluene;
DOI:10.1021/ja309003x DOI:10.1021/ja309003x

Reference yield:

: 1402852-67-8
2-(3,4-dichlorophenyl)oxazol-5(4H)-one

: 1402852-72-5
(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 6-cyclohexyl-2-(3,4-dichlorophenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum oxide / dichloromethane / 2 h / Inert atmosphere

2: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium(0) chloroform complex / toluene / 16.83 h / 20 °C / Inert atmosphere

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); aluminum oxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In dichloromethane; toluene;
DOI:10.1021/ja309003x DOI:10.1021/ja309003x