2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

Base Information

Chemical Name:2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine
CAS No.:1392425-85-2
Molecular Formula:C₁₈H₁₅F₃N₄O
Molecular Weight:360.339
Hs Code.:

Synonyms:2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

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Chemical Property of 2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

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Technology Process of 2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

There total 5 articles about 2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392425-66-9
(2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropyl)carbamic acid tert-butyl ester

: 1392425-85-2
2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

Guidance literature:: (2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropyl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

With triethylamine; In dichloromethane; for 1h;

Reference yield:

: 1392425-52-3
1-(4-Chloro-2-methylphenyl)-3-(2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropyl)thiourea

: 1392425-85-2
2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

Guidance literature:: With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: (x)C₂HF₃O₂*C₁₉H₁₄F₃N₃O₃

: 1392425-85-2
2-{4-[1-(4-trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]phenyl}cyclopropylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 25 °C

2.1: toluene / 24 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

3.2: 1 h

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;