2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate
CAS No.:1379604-39-3
Molecular Formula:C₂₂H₂₃N₃O₅SSi
Molecular Weight:469.593
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

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Chemical Property of 2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

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Technology Process of 2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

There total 4 articles about 2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1072106-27-4
2-(trimethylsilyl)ethyl-4-(1-bromoethyl)-3-nitrobenzoate

: 939-69-5
2-cyano-6-hydroxybenzothiazole

: 1379604-39-3
2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

Guidance literature:: With potassium carbonate; In acetone; for 2h; Reflux;
DOI:10.1002/anie.201107919

Reference yield:

: 103440-95-5
4-Ethyl-3-nitrobenzoic acid

: 1379604-39-3
2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / tetrahydrofuran / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h

3: N-Bromosuccinimide; dibenzoyl peroxide / benzene / Reflux

4: potassium carbonate / acetone / 2 h / Reflux

With N-Bromosuccinimide; thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; acetone; benzene;
DOI:10.1002/anie.201107919

Reference yield:

: 619-64-7
p-ethylbenzoic acid

: 1379604-39-3
2-(trimethylsilyl)ethyl-4-(1-(2-cyanobenzo[d]thiazol-6-yloxy)ethyl)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 1 h / 0 °C

2: thionyl chloride / tetrahydrofuran / 2 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h

4: N-Bromosuccinimide; dibenzoyl peroxide / benzene / Reflux

5: potassium carbonate / acetone / 2 h / Reflux

With N-Bromosuccinimide; thionyl chloride; sulfuric acid; nitric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; acetone; benzene;
DOI:10.1002/anie.201107919