prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

Base Information

Chemical Name:prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate
CAS No.:1431877-95-0
Molecular Formula:C₃₅H₄₄F₃N₃O₆SSi
Molecular Weight:719.898
Hs Code.:

prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

Synonyms:prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

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Chemical Property of prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

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Technology Process of prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

There total 5 articles about prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431877-94-9
prop-2-en-1-yl [(1R)-1-{5-[(1S)-1-amino-2,2,2-trifluoroethyl]thiophen-2-yl}-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl]carbamate

: 161869-03-0
(S)-2-((methoxycarbonyl)amino)-3,3-diphenylpropanoic acid

: 1431877-95-0
prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

Guidance literature:: (S)-2-((methoxycarbonyl)amino)-3,3-diphenylpropanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -15 ℃; for 0.5h;

prop-2-en-1-yl [(1R)-1-{5-[(1S)-1-amino-2,2,2-trifluoroethyl]thiophen-2-yl}-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl]carbamate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 20 ℃;

Reference yield:

: 1431877-90-5
(6R)-2,2,3,3,9,9-hexamethyl-6-(thiophen-2-yl)-4-oxa-8-thionia-7-aza-3-siladecan-8-olate

: 1431877-95-0
prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.25 h / -25 - -22 °C

1.2: -65 - -60 °C

2.1: hydrogenchloride / methanol; water / 2 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -15 °C

4.2: -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; hexane; dichloromethane; water;

Reference yield:

: 1431877-92-7
(6R)-6-{5-[(1S)-1-{ [tert-butyl(oxido)sulfonio]amino}-2,2,2-trifluoroethyl]thiophen-2-yl}-2,2,3,3,9,9-hexamethyl-4-oxa-8-thionia-7-aza-3-siladecan-8-olate

: 1431877-95-0
prop-2-en-1-yl [(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[(1S)-2,2,2-trifluoro-1-{[N-(methoxycarbonyl)-b-phenyl-L-phenylalanyl]amino}ethyl]thiophen-2-yl}ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; water / 2 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / -15 °C

3.2: -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In methanol; dichloromethane; water;