3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:474925-19-4
Molecular Formula:C₂₂H₂₇NO₂
Molecular Weight:337.462
Hs Code.:

Synonyms:3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-67-3
nitrostyrene

: 474925-19-4
3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: (-)-sparteine; n-BuLi / toluene; hexane / -78 °C

1.2: toluene; hexane / -78 °C

2.1: aq. HCl / CHCl₃

3.1: 2-methyl-2-butene; aq. NaClO₄; NaH₂PO₄ / 2-methyl-propan-2-ol

4.1: HCl

5.1: H₂ / Raney Ni / methanol / 12929 Torr

6.1: NaH / tetrahydrofuran / 20 °C

7.1: t-BuLi / pentane

7.2: 74 percent / pentane

8.1: 90 percent / H₂O₂ / ethyl acetate; H₂O / 0.5 h

9.1: H₂ / Pd(OH)2 / ethyl acetate / 17 h / 12929 Torr

9.2: 0.332 g / LAH / tetrahydrofuran / 16 h / Heating

10.1: 78 percent / H₂ / Pd(OH)2 / ethyl acetate / 18 h / 760.05 Torr

With hydrogenchloride; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; sodium perchlorate; hydrogen; dihydrogen peroxide; tert.-butyl lithium; sodium hydride; (-)-sparteine; palladium dihydroxide; nickel; In tetrahydrofuran; methanol; hexane; chloroform; water; ethyl acetate; toluene; tert-butyl alcohol; pentane;
DOI:10.1021/ja0271375

Reference yield:

: 474925-65-0
1-benzyl-4,5-diphenyl-3-phenylselenyl-piperidin-2-one

: 474925-19-4
3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / H₂O₂ / ethyl acetate; H₂O / 0.5 h

2.1: H₂ / Pd(OH)2 / ethyl acetate / 17 h / 12929 Torr

2.2: 0.332 g / LAH / tetrahydrofuran / 16 h / Heating

3.1: 78 percent / H₂ / Pd(OH)2 / ethyl acetate / 18 h / 760.05 Torr

With hydrogen; dihydrogen peroxide; palladium dihydroxide; In water; ethyl acetate;
DOI:10.1021/ja0271375

Reference yield:

: N-(tert-butoxycabonyl)-N-(4-methoxyphenyl)-3-phenyl-(E)-2-propen-1-amine

: 474925-19-4
3,4-diphenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: (-)-sparteine; n-BuLi / toluene; hexane / -78 °C

1.2: toluene; hexane / -78 °C

2.1: aq. HCl / CHCl₃

3.1: 2-methyl-2-butene; aq. NaClO₄; NaH₂PO₄ / 2-methyl-propan-2-ol

4.1: HCl

5.1: H₂ / Raney Ni / methanol / 12929 Torr

6.1: NaH / tetrahydrofuran / 20 °C

7.1: t-BuLi / pentane

7.2: 74 percent / pentane

8.1: 90 percent / H₂O₂ / ethyl acetate; H₂O / 0.5 h

9.1: H₂ / Pd(OH)2 / ethyl acetate / 17 h / 12929 Torr

9.2: 0.332 g / LAH / tetrahydrofuran / 16 h / Heating

10.1: 78 percent / H₂ / Pd(OH)2 / ethyl acetate / 18 h / 760.05 Torr

With hydrogenchloride; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; sodium perchlorate; hydrogen; dihydrogen peroxide; tert.-butyl lithium; sodium hydride; (-)-sparteine; palladium dihydroxide; nickel; In tetrahydrofuran; methanol; hexane; chloroform; water; ethyl acetate; toluene; tert-butyl alcohol; pentane;
DOI:10.1021/ja0271375