3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

Base Information

Chemical Name:3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole
CAS No.:1285572-57-7
Molecular Formula:C₁₆H₉F₃N₂O₄S
Molecular Weight:382.32
Hs Code.:

Synonyms:3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

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Chemical Property of 3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

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Technology Process of 3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

There total 12 articles about 3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285573-75-2
3-(3-cyano-4-methoxy-5-trifluoromethylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

: 1285572-57-7
3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

Guidance literature:: 3-(3-cyano-4-methoxy-5-trifluoromethylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole; With lithium chloride; In N,N-dimethyl-formamide; at 70 ℃; for 2h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 1285573-58-1
5-bromo-1-diethoxymethyl-2-methoxy-3-trifluoromethylbenzene

: 1285572-57-7
3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

1.2: 1 h / 0 °C

1.3: 16 h / 20 °C

2.1: formic acid; hydroxylamine hydrochloride / 19 h / Reflux

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 16 h / 60 °C

4.1: triethylamine / chloroform / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 h / 20 °C

6.1: lithium chloride / N,N-dimethyl-formamide / 2 h / 70 °C

With formic acid; thionyl chloride; hydroxylamine hydrochloride; magnesium; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1285573-65-0
5-cyano-4-methoxy-3-trifluoromethylbenzoic acid

: 1285572-57-7
3-(3-cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / toluene / 16 h / 60 °C

2: triethylamine / chloroform / 1 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 h / 20 °C

4: lithium chloride / N,N-dimethyl-formamide / 2 h / 70 °C

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium chloride; N,N-dimethyl-formamide; In chloroform; N,N-dimethyl-formamide; toluene;